Mnova Verify

Mnova Verify is a new developing approach for structure verification by NMR and MS.

The pharmaceutical and biotechnology industries are currently facing very significant challenges which are resulting on major organizational and operational changes. The trend is for pharmaceutical companies to outsource many of their Research and Development operations to third parties with specific specialties and areas of expertise, in order to focus their own resources on areas where they are in a position to maximize value.

As a result, where many operations such as data mining, information sharing and decisions on chemical entities used to have to be carried out at an internal company level, now these same functions need to encompass the entirety of the supply chain and all partners involved in the company´s R&D effort. In addition, it is desirable to standardize data formats and data handling as much as possible, to keep tight controls on quality, particularly when compounds are being transferred between organizations and to optimize the sharing of information to maximize productivity.

A further challenge, which affects, among others, the domain of Analytical Data, is the reduction in the resourcing of internal support teams. In the case of Analytical Data, this means that, whilst progress in hardware capabilities and huge steps forward in automation allow us to generate very large amounts of analytical data in high throughput, a bottleneck is being created by the capability of Analytical Departments to get eyes on data. In this situation, overseeing also the data and proposed chemical structures proposed by partners outside the organization, and typically received in large numbers, is becoming harder and in most cases has been abandoned as an achievable objective.

Mnova Verify evaluates a series of elements (GSD, solvent recognition, novel similarity measure, multiplets and chemical shift predictions) and applies a scoring system to return a Yes/No/I don´t know answer. This makes it a very powerful screening system useful for chemists who need to validate decisions as to the structure corresponding to their experiments, either in single or batch mode.